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KMID : 1149220180260030237
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Korean Journal of Oriental Medical Prescription
2018 Volume.26 No. 3 p.237 ~ p.250
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Pharmacological Systemic Analysis of Curcumae Radix in Lipid Metabolism
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Jo Han-Byeol
Kim Ji-Young
Kim Min-Sung
An Won-Gun
Lee Jang-Cheon
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Abstract
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Objectives : This study is a pharmacological network approach, aimed to identify the potential active compounds contained in Curcumae Radix, and their associated targets, to predict the various bio-reactions involved, and finally to establish the cornerstone for the deep-depth study of the representative mechanisms.
Methods : The active compounds of Curcumae Radix have been identified using Traditional Chinese Medicine System Pharmacology Database and Analysis Platform. The UniProt database was used to collect each of information of all target proteins associated with the active compounds. To find the bio-metabolic processes associated with each target, the DAVID6.8 Gene Functional classifier tool was used. Compound-Target and Target-Pathway networks were analyzed via Cytoscape 3.40.
Results : The target information from 32 potential active compounds of Curcumae Radix was collected through TCMSP analysis. The active compounds interact with 133 target genes engaging in total of 885 biological pathways. The most relevant pathway was the lipid-related metabolism, in which 3 representative active compounds were naringenin, oleic acid, and β-sitosterol. The mostly targeted proteins in the lipid pathway were ApoB, AKT1 and PPAR.
Conclusions : The pharmacological network analysis is convenient approach to predict the overall metabolic mechanisms in medicinal herb research, which can reduce the processes of various experimental trial and error and provide key clues that can be used to validate and experimentally verify the core compounds.
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KEYWORD
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TCMSP analysis, Curcumae Radix, pharmacological network analysis
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